Synthesis and Biomedical Application of SiO2/Au Nanofluid Based on Laser-Induced Surface Plasmon Resonance Thermal Effect

We described the synthesis of Au coated SiO2 nanoshells linked with NH2 biomolecular ligands using a simple wet chemical method with a particular application for laser tissue soldering. Tunable nanoshells were prepared by using different gold colloidal concentrations. The nanoshells are characterized by UV-vis spectroscopy, FTIR, XRD and AFM. The FTIR results confirmed the functionalized surfaces of silica nanoparticles with NH2 terminal groups. A broad absorption was observed between 470 600 nm with a maximum range between 530 560 nm. Based on the XRD results three main peaks of Au (111), (200) and (220) were identified. In addition, AFM results showed that the diameter of silica core was between 90 110 nm with gold shell thickness between 10 30 nm. A possible tissue soldering using gold nanoshells and laser-induced thermal effect based on surface plasmon resonance is demonstrated. In our case this corresponds to 90 ̊C (i.e. below vaporization) using the higher gold concentration (2 ml) at 60 W·cm.